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Human Nuclease-sensitive element-binding protein 1 (aa 2-324)

NSEP1 Swiss Prot#

P67809

NSEP1 Protein names

Nuclease-sensitive element-binding protein 1 (Y-box-binding protein 1) (Y-box transcription factor) (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (Enhancer factor I subunit A) (EFI-A) (DNA-binding protein B) (DBPB)

NSEP1 Gene names

YBX1 (NSEP1) (YB1)

Organism

Human

NSEP1 Entry name

YBOX1_HUMAN

NSEP1 Codon optimized cDNA(gene) Clone

NSEP1 Cat #

RPE0110

Tag

NSEP1 contains A 6x histidine tag

NSEP1 Formulation

Liquid

NSEP1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

NSEP1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant NSEP1 Protein

NSEP1 Cat #

PE0110

NSEP1 Source

recombinant

NSEP1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

NSEP1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

NSEP1 Activity

N/A

Tag

NSEP1 Contains A 6x histidine tag

NSEP1 Formulation

Liquid

NSEP1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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NSEP1 family

-

NSEP1 Subcellular locations

Cytoplasm. Nucleus. Cytoplasmic granule. Secreted.

NSEP1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.; FUNCTION: The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.

NSEP1 Sequence

DDBJ

EMBL

GenBank

NSEP1 3D structure

ModBase

NSEP1 interaction

STRING

NSEP1 Proteomic

PRIDE

NSEP1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

NSEP1 Organism specific

CTD

MGI

NSEP1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NSEP1 Gene expression

Bgee

ArrayExpress

Genevestigator

NSEP1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY