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Human Nucleophosmin (aa 1-294)

NPM Swiss Prot#

P06748

NPM Protein names

Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin) (Nucleolar protein NO38)

NPM Gene names

NPM1 (NPM)

Organism

Human

NPM Entry name

NPM_HUMAN

NPM Codon optimized cDNA(gene) Clone

NPM Cat #

RPE0090

Tag

NPM contains A 6x histidine tag

NPM Formulation

Liquid

NPM Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

NPM Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant NPM Protein

NPM Cat #

PE0090

NPM Source

recombinant

NPM Applications

Western Blot, SDS-Page or may be used for other applications determined by user

NPM Purity

>90%, as determined by SDS-PAGE under reducing conditions

NPM Activity

N/A

Tag

NPM Contains A 6x histidine tag

NPM Formulation

Liquid

NPM Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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NPM family

Nucleoplasmin family

NPM Subcellular locations

Nucleus > nucleolus. Nucleus > nucleoplasm.

NPM FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules.

NPM Sequence

DDBJ

EMBL

GenBank

NPM 3D structure

ModBase

NPM interaction

STRING

NPM Proteomic

PRIDE

NPM Genome annotation

Ensembl

GeneID

KEGG

UCSC

NPM Organism specific

CTD

MGI

NPM Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NPM Gene expression

Bgee

ArrayExpress

Genevestigator

NPM Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY