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Human Kallikrein-8 (aa 33-260)

NRPN Swiss Prot#

O60259

NRPN Protein names

Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein) (Serine protease 19)

NRPN Gene names

KLK8 (NRPN) (PRSS19) (TADG14) (UNQ283/PRO322)

Organism

Human

NRPN Entry name

KLK8_HUMAN

NRPN Codon optimized cDNA(gene) Clone

NRPN Cat #

RPE0077

Tag

NRPN contains A 6x histidine tag

NRPN Formulation

Liquid

NRPN Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

NRPN Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant NRPN Protein

NRPN Cat #

PE0077

NRPN Source

recombinant

NRPN Applications

Western Blot, SDS-Page or may be used for other applications determined by user

NRPN Purity

>90%, as determined by SDS-PAGE under reducing conditions

NRPN Activity

N/A

Tag

NRPN Contains A 6x histidine tag

NRPN Formulation

Liquid

NRPN Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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NRPN family

Peptidase S1 family, Kallikrein subfamily

NRPN Subcellular locations

Secreted. Cytoplasm.

NRPN FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.

NRPN Sequence

DDBJ

EMBL

GenBank

NRPN 3D structure

ModBase

NRPN interaction

STRING

NRPN Proteomic

PRIDE

NRPN Genome annotation

Ensembl

GeneID

KEGG

UCSC

NRPN Organism specific

CTD

MGI

NRPN Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NRPN Gene expression

Bgee

ArrayExpress

Genevestigator

NRPN Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY