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Human Major prion protein (aa 23-230)

PRIP Swiss Prot#

P04156

PRIP Protein names

Major prion protein (PrP) (PrP27-30) (PrP33-35C) (ASCR) (CD antigen CD230)

PRIP Gene names

PRNP (PRIP) (PRP)

Organism

Human

PRIP Entry name

PRIO_HUMAN

PRIP Codon optimized cDNA(gene) Clone

PRIP Cat #

RPE0072

Tag

PRIP contains A 6x histidine tag

PRIP Formulation

Liquid

PRIP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PRIP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PRIP Protein

PRIP Cat #

PE0072

PRIP Source

recombinant

PRIP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PRIP Purity

>90%, as determined by SDS-PAGE under reducing conditions

PRIP Activity

N/A

Tag

PRIP Contains A 6x histidine tag

PRIP Formulation

Liquid

PRIP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PRIP family

Prion family

PRIP Subcellular locations

Cell membrane; Lipid-anchor > GPI-anchor. Golgi apparatus. Cytoplasm. Nucleus.

PRIP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: The function of PrP is still under debate. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis (By similarity). Isoform 2 may act as a growth suppressor by arresting the cell cycle at the G0/G1 phase. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).

PRIP Sequence

DDBJ

EMBL

GenBank

PRIP 3D structure

ModBase

PRIP interaction

STRING

PRIP Proteomic

PRIDE

PRIP Genome annotation

Ensembl

GeneID

KEGG

UCSC

PRIP Organism specific

CTD

MGI

PRIP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PRIP Gene expression

Bgee

ArrayExpress

Genevestigator

PRIP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY