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Human Neutrophil gelatinase-associated lipocalin (aa 21-198)

HNL Swiss Prot#

P80188

HNL Protein names

Neutrophil gelatinase-associated lipocalin (NGAL) (p25) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3)

HNL Gene names

LCN2 (HNL) (NGAL)

Organism

Human

HNL Entry name

NGAL_HUMAN

HNL Codon optimized cDNA(gene) Clone

HNL Cat #

RPE0043

Tag

HNL contains A 6x histidine tag

HNL Formulation

Liquid

HNL Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

HNL Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant HNL Protein

HNL Cat #

PE0043

HNL Source

recombinant

HNL Applications

Western Blot, SDS-Page or may be used for other applications determined by user

HNL Purity

>90%, as determined by SDS-PAGE under reducing conditions

HNL Activity

N/A

Tag

HNL Contains A 6x histidine tag

HNL Formulation

Liquid

HNL Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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HNL family

Calycin superfamily, Lipocalin family

HNL Subcellular locations

Secreted.

HNL FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

HNL Sequence

DDBJ

EMBL

GenBank

HNL 3D structure

ModBase

HNL interaction

STRING

HNL Proteomic

PRIDE

HNL Genome annotation

Ensembl

GeneID

KEGG

UCSC

HNL Organism specific

CTD

MGI

HNL Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

HNL Gene expression

Bgee

ArrayExpress

Genevestigator

HNL Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY