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| Human Charged multivesicular body protein 1a (aa 1-196) |
| CHMP1 Swiss Prot# | | Q9HD42 |
| CHMP1 Protein names | | Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein-sorting-associated protein 46-1) (Vps46-1) (hVps46-1) |
| CHMP1 Gene names | | CHMP1A (CHMP1) (KIAA0047) (PCOLN3) (PRSM1) |
| Organism | | Human |
| CHMP1 Entry name | | CHM1A_HUMAN |
| CHMP1 Codon optimized cDNA(gene) Clone |
| CHMP1 Cat # | | RPE0041 |
| Tag | | CHMP1 contains A 6x histidine tag |
| CHMP1 Formulation | | Liquid |
| CHMP1 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| CHMP1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant CHMP1 Protein |
| CHMP1 Cat # | | PE0041 |
| CHMP1 Source | | recombinant |
| CHMP1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| CHMP1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| CHMP1 Activity | | N/A |
| Tag | | CHMP1 Contains A 6x histidine tag |
| CHMP1 Formulation | | Liquid |
| CHMP1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CHMP1 Products | | For pricing and availability Click Here >>> |
| CHMP1 family | | SNF7 family |
| CHMP1 Subcellular locations | | Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. |
| CHMP1 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. |
| CHMP1 Sequence | | DDBJ | EMBL | GenBank |
| CHMP1 3D structure | | ModBase |
| CHMP1 interaction | | STRING |
| CHMP1 Proteomic | | PRIDE |
| CHMP1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| CHMP1 Organism specific | | CTD | MGI |
| CHMP1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CHMP1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| CHMP1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
