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Human Calcium-activated potassium channel subunit beta-1 (aa 40-157)

KCNMB1 Swiss Prot#

Q16558

KCNMB1 Protein names

Calcium-activated potassium channel subunit beta-1 (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Maxi K channel subunit beta-1) (BK channel subunit beta-1) (BKbeta1) (BKbeta) (Hbeta1) (K(VCA)beta-1) (Slo-beta-1) (Slo-beta) (Charybdotoxin receptor subunit beta-1)

KCNMB1 Gene names

KCNMB1

Organism

Human

KCNMB1 Entry name

KCMB1_HUMAN

KCNMB1 Codon optimized cDNA(gene) Clone

KCNMB1 Cat #

RPE0038

Tag

KCNMB1 contains A 6x histidine tag

KCNMB1 Formulation

Liquid

KCNMB1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

KCNMB1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant KCNMB1 Protein

KCNMB1 Cat #

PE0038

KCNMB1 Source

recombinant

KCNMB1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

KCNMB1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

KCNMB1 Activity

N/A

Tag

KCNMB1 Contains A 6x histidine tag

KCNMB1 Formulation

Liquid

KCNMB1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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KCNMB1 family

KCNMB (TC 8.A.14.1) family, KCNMB1 subfamily

KCNMB1 Subcellular locations

Membrane; Multi-pass membrane protein.

KCNMB1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

KCNMB1 Sequence

DDBJ

EMBL

GenBank

KCNMB1 3D structure

ModBase

KCNMB1 interaction

STRING

KCNMB1 Proteomic

PRIDE

KCNMB1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

KCNMB1 Organism specific

CTD

MGI

KCNMB1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

KCNMB1 Gene expression

Bgee

ArrayExpress

Genevestigator

KCNMB1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY