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Human Parathyroid hormone-related protein (aa 37-177)
PTHRP Swiss Prot#
P12272
PTHRP Protein names
Parathyroid hormone-related protein (PTH-rP) (PTHrP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]
PTHRP Gene names
PTHLH (PTHRP)
Organism
Human
PTHRP Entry name
PTHR_HUMAN
PTHRP Codon optimized cDNA(gene) Clone
PTHRP Cat #
RPE0036
Tag
PTHRP contains A 6x histidine tag
PTHRP Formulation
Liquid
PTHRP Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
PTHRP Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant PTHRP Protein
PTHRP Cat #
PE0036
PTHRP Source
recombinant
PTHRP Applications
Western Blot, SDS-Page or may be used for other applications determined by user
PTHRP Purity
>90%, as determined by SDS-PAGE under reducing conditions
PTHRP Activity
N/A
Tag
PTHRP Contains A 6x histidine tag
PTHRP Formulation
Liquid
PTHRP Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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PTHRP family
Parathyroid hormone family
PTHRP Subcellular locations
Cytoplasm. Nucleus. Secreted.
PTHRP FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.; FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
PTHRP Sequence
DDBJ EMBL GenBank
PTHRP 3D structure
ModBase
PTHRP interaction
STRING
PTHRP Proteomic
PRIDE
PTHRP Genome annotation
Ensembl GeneID KEGG UCSC
PTHRP Organism specific
CTD MGI
PTHRP Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PTHRP Gene expression
Bgee ArrayExpress Genevestigator
PTHRP Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY