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| Human Centrin-2 (aa 1-172) |
| CALT Swiss Prot# | | P41208 |
| CALT Protein names | | Centrin-2 (Caltractin isoform 1) |
| CALT Gene names | | CETN2 (CALT) (CEN2) |
| Organism | | Human |
| CALT Entry name | | CETN2_HUMAN |
| CALT Codon optimized cDNA(gene) Clone |
| CALT Cat # | | RPE0030 |
| Tag | | CALT contains A 6x histidine tag |
| CALT Formulation | | Liquid |
| CALT Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| CALT Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant CALT Protein |
| CALT Cat # | | PE0030 |
| CALT Source | | recombinant |
| CALT Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| CALT Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| CALT Activity | | N/A |
| Tag | | CALT Contains A 6x histidine tag |
| CALT Formulation | | Liquid |
| CALT Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CALT Products | | For pricing and availability Click Here >>> |
| CALT family | | Centrin family |
| CALT Subcellular locations | | Cytoplasm > cytoskeleton > centrosome > centriole. Nucleus. |
| CALT FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Plays a fundamental role in microtubule-organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CEP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. |
| CALT Sequence | | DDBJ | EMBL | GenBank |
| CALT 3D structure | | ModBase |
| CALT interaction | | STRING |
| CALT Proteomic | | PRIDE |
| CALT Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| CALT Organism specific | | CTD | MGI |
| CALT Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CALT Gene expression | | Bgee | ArrayExpress | Genevestigator |
| CALT Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
