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Human Ubiquitin-conjugating enzyme E2 A (aa 1-152)

RAD6A Swiss Prot#

P49459

RAD6A Protein names

Ubiquitin-conjugating enzyme E2 A (EC 6.3.2.19) (Ubiquitin-protein ligase A) (Ubiquitin carrier protein A) (HR6A) (hHR6A)

RAD6A Gene names

UBE2A (RAD6A)

Organism

Human

RAD6A Entry name

UBE2A_HUMAN

RAD6A Codon optimized cDNA(gene) Clone

RAD6A Cat #

RPE0020

Tag

RAD6A contains A 6x histidine tag

RAD6A Formulation

Liquid

RAD6A Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RAD6A Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RAD6A Protein

RAD6A Cat #

PE0020

RAD6A Source

recombinant

RAD6A Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RAD6A Purity

>90%, as determined by SDS-PAGE under reducing conditions

RAD6A Activity

N/A

Tag

RAD6A Contains A 6x histidine tag

RAD6A Formulation

Liquid

RAD6A Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RAD6A family

Ubiquitin-conjugating enzyme family

RAD6A Subcellular locations

-

RAD6A FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

RAD6A Sequence

DDBJ

EMBL

GenBank

RAD6A 3D structure

ModBase

RAD6A interaction

STRING

RAD6A Proteomic

PRIDE

RAD6A Genome annotation

Ensembl

GeneID

KEGG

UCSC

RAD6A Organism specific

CTD

MGI

RAD6A Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RAD6A Gene expression

Bgee

ArrayExpress

Genevestigator

RAD6A Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY