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| Rat cd98 (aa 99 – 527) |
| Slc3a2 Swiss Prot# | | Q794F9 |
| Slc3a2 Protein names | | 4F2 cell-surface antigen heavy chain (4F2hc) (CD antigen CD98) |
| Slc3a2 Gene names | | Slc3a2 |
| Organism | | Rat |
| Slc3a2 Entry name | | 4F2_RAT |
| Slc3a2 Codon optimized cDNA(gene) Clone |
| Slc3a2 Cat # | | RPV0897 |
| Tag | | Slc3a2 contains A 6x histidine tag |
| Slc3a2 Formulation | | Liquid |
| Slc3a2 Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Slc3a2 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Slc3a2 Protein |
| Slc3a2 Cat # | | PV0897 |
| Slc3a2 Source | | recombinant. |
| Slc3a2 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Slc3a2 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Slc3a2 Activity | | N/A |
| Tag | | Slc3a2 Contains A 6x histidine tag |
| Slc3a2 Formulation | | Liquid |
| Slc3a2 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Slc3a2 Products | | For pricing and availability Click Here >>> |
| Slc3a2 family | | SUBUNIT: Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins (By similarity). Interacts with FAM57A/CT120 and ICAM1 (By similarity). Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1 (By similarity). |
| Slc3a2 Subcellular locations | | SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type II membrane protein. Melanosome (By similarity). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Localized to the plasma membrane when associated with SLC7A5 or SLC7A8 (By similarity). Localized to the placental apical membrane (By similarity). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia (By similarity). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. |
| Slc3a2 FUNCTION According to UniProtKB Swiss Prot | | Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. |
| Slc3a2 Sequence | | DDBJ | EMBL | GenBank |
| Slc3a2 3D structure | | ModBase |
| Slc3a2 interaction | | STRING |
| Slc3a2 Proteomic | | PRIDE |
| Slc3a2 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Slc3a2 Organism specific | | CTD | MGI |
| Slc3a2 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Slc3a2 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Slc3a2 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
