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Human CD95 (aa 26 – 173)

APT1 Swiss Prot#

P25445

APT1 Protein names

Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)

APT1 Gene names

FAS APT1 FAS1 TNFRSF6

Organism

Human

APT1 Entry name

TNR6_HUMAN

APT1 Codon optimized cDNA(gene) Clone

APT1 Cat #

RPV0886

Tag

APT1 contains A 6x histidine tag

APT1 Formulation

Liquid

APT1 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

APT1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant APT1 Protein

APT1 Cat #

PV0886

APT1 Source

recombinant.

APT1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

APT1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

APT1 Activity

N/A

Tag

APT1 Contains A 6x histidine tag

APT1 Formulation

Liquid

APT1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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APT1 family

SUBUNIT: Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD.

APT1 Subcellular locations

SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform 2: Secreted. ; SUBCELLULAR LOCATION: Isoform 3: Secreted. ; SUBCELLULAR LOCATION: Isoform 4: Secreted. ; SUBCELLULAR LOCATION: Isoform 5: Secreted. ; SUBCELLULAR LOCATION: Isoform 6: Secreted.

APT1 FUNCTION According to UniProtKB Swiss Prot

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

APT1 Sequence

DDBJ

EMBL

GenBank

APT1 3D structure

ModBase

APT1 interaction

STRING

APT1 Proteomic

PRIDE

APT1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

APT1 Organism specific

CTD

MGI

APT1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

APT1 Gene expression

Bgee

ArrayExpress

Genevestigator

APT1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY