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| Human CD8a (aa 22 – 182) |
| MAL Swiss Prot# | | P01732 |
| MAL Protein names | | T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a) |
| MAL Gene names | | CD8A MAL |
| Organism | | Human |
| MAL Entry name | | CD8A_HUMAN |
| MAL Codon optimized cDNA(gene) Clone |
| MAL Cat # | | RPV0864 |
| Tag | | MAL contains A 6x histidine tag |
| MAL Formulation | | Liquid |
| MAL Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| MAL Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant MAL Protein |
| MAL Cat # | | PV0864 |
| MAL Source | | recombinant. |
| MAL Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| MAL Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| MAL Activity | | N/A |
| Tag | | MAL Contains A 6x histidine tag |
| MAL Formulation | | Liquid |
| MAL Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant MAL Products | | For pricing and availability Click Here >>> |
| MAL family | | SUBUNIT: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. |
| MAL Subcellular locations | | SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform 2: Secreted. |
| MAL FUNCTION According to UniProtKB Swiss Prot | | Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. |
| MAL Sequence | | DDBJ | EMBL | GenBank |
| MAL 3D structure | | ModBase |
| MAL interaction | | STRING |
| MAL Proteomic | | PRIDE |
| MAL Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| MAL Organism specific | | CTD | MGI |
| MAL Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| MAL Gene expression | | Bgee | ArrayExpress | Genevestigator |
| MAL Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |