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Human CD85j (aa 24 – 461)

ILT2 Swiss Prot#

Q8NHL6

ILT2 Protein names

Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)

ILT2 Gene names

LILRB1 ILT2 LIR1 MIR7

Organism

Human

ILT2 Entry name

LIRB1_HUMAN

ILT2 Codon optimized cDNA(gene) Clone

ILT2 Cat #

RPV0849

Tag

ILT2 contains A 6x histidine tag

ILT2 Formulation

Liquid

ILT2 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ILT2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ILT2 Protein

ILT2 Cat #

PV0849

ILT2 Source

recombinant.

ILT2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ILT2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ILT2 Activity

N/A

Tag

ILT2 Contains A 6x histidine tag

ILT2 Formulation

Liquid

ILT2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ILT2 family

SUBUNIT: Binds PTPN6 when phosphorylated. Binds FCER1A and FCGR1A.

ILT2 Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

ILT2 FUNCTION According to UniProtKB Swiss Prot

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

ILT2 Sequence

DDBJ

EMBL

GenBank

ILT2 3D structure

ModBase

ILT2 interaction

STRING

ILT2 Proteomic

PRIDE

ILT2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ILT2 Organism specific

CTD

MGI

ILT2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ILT2 Gene expression

Bgee

ArrayExpress

Genevestigator

ILT2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY