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Human cd79a (aa 33 – 143)

IGA Swiss Prot#

P11912

IGA Protein names

B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)

IGA Gene names

CD79A IGA MB1

Organism

Human

IGA Entry name

CD79A_HUMAN

IGA Codon optimized cDNA(gene) Clone

IGA Cat #

RPV0819

Tag

IGA contains A 6x histidine tag

IGA Formulation

Liquid

IGA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

IGA Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant IGA Protein

IGA Cat #

PV0819

IGA Source

recombinant.

IGA Applications

Western Blot, SDS-Page or may be used for other applications determined by user

IGA Purity

>90%, as determined by SDS-PAGE under reducing conditions

IGA Activity

N/A

Tag

IGA Contains A 6x histidine tag

IGA Formulation

Liquid

IGA Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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IGA family

SUBUNIT: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-210, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).

IGA Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity).

IGA FUNCTION According to UniProtKB Swiss Prot

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells.

IGA Sequence

DDBJ

EMBL

GenBank

IGA 3D structure

ModBase

IGA interaction

STRING

IGA Proteomic

PRIDE

IGA Genome annotation

Ensembl

GeneID

KEGG

UCSC

IGA Organism specific

CTD

MGI

IGA Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

IGA Gene expression

Bgee

ArrayExpress

Genevestigator

IGA Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY