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Human cd74 (aa 73 – 296)

DHLAG Swiss Prot#

P04233

DHLAG Protein names

HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD antigen CD74)

DHLAG Gene names

CD74 DHLAG

Organism

Human

DHLAG Entry name

HG2A_HUMAN

DHLAG Codon optimized cDNA(gene) Clone

DHLAG Cat #

RPV0813

Tag

DHLAG contains A 6x histidine tag

DHLAG Formulation

Liquid

DHLAG Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

DHLAG Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant DHLAG Protein

DHLAG Cat #

PV0813

DHLAG Source

recombinant.

DHLAG Applications

Western Blot, SDS-Page or may be used for other applications determined by user

DHLAG Purity

>90%, as determined by SDS-PAGE under reducing conditions

DHLAG Activity

N/A

Tag

DHLAG Contains A 6x histidine tag

DHLAG Formulation

Liquid

DHLAG Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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DHLAG family

SUBUNIT: Homotrimer. In the endoplasmic reticulum (ER) it forms an heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.

DHLAG Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

DHLAG FUNCTION According to UniProtKB Swiss Prot

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

DHLAG Sequence

DDBJ

EMBL

GenBank

DHLAG 3D structure

ModBase

DHLAG interaction

STRING

DHLAG Proteomic

PRIDE

DHLAG Genome annotation

Ensembl

GeneID

KEGG

UCSC

DHLAG Organism specific

CTD

MGI

DHLAG Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

DHLAG Gene expression

Bgee

ArrayExpress

Genevestigator

DHLAG Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY