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Rat cd71 (aa 431 – 622)

Trfr Swiss Prot#

Q99376

Trfr Protein names

Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (CD antigen CD71) (Fragment)

Trfr Gene names

Tfrc Trfr

Organism

Rat

Trfr Entry name

TFR1_RAT

Trfr Codon optimized cDNA(gene) Clone

Trfr Cat #

RPV0806

Tag

Trfr contains A 6x histidine tag

Trfr Formulation

Liquid

Trfr Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Trfr Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Trfr Protein

Trfr Cat #

PV0806

Trfr Source

recombinant.

Trfr Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Trfr Purity

>90%, as determined by SDS-PAGE under reducing conditions

Trfr Activity

N/A

Tag

Trfr Contains A 6x histidine tag

Trfr Formulation

Liquid

Trfr Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Trfr family

SUBUNIT: Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4 (By similarity).

Trfr Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein (By similarity). Melanosome (By similarity).

Trfr FUNCTION According to UniProtKB Swiss Prot

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).

Trfr Sequence

DDBJ

EMBL

GenBank

Trfr 3D structure

ModBase

Trfr interaction

STRING

Trfr Proteomic

PRIDE

Trfr Genome annotation

Ensembl

GeneID

KEGG

UCSC

Trfr Organism specific

CTD

MGI

Trfr Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Trfr Gene expression

Bgee

ArrayExpress

Genevestigator

Trfr Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY