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Human cd71 (aa 569 – 760)

TFRC Swiss Prot#

P02786

TFRC Protein names

Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]

TFRC Gene names

TFRC

Organism

Human

TFRC Entry name

TFR1_HUMAN

TFRC Codon optimized cDNA(gene) Clone

TFRC Cat #

RPV0804

Tag

TFRC contains A 6x histidine tag

TFRC Formulation

Liquid

TFRC Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TFRC Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TFRC Protein

TFRC Cat #

PV0804

TFRC Source

recombinant.

TFRC Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TFRC Purity

>90%, as determined by SDS-PAGE under reducing conditions

TFRC Activity

N/A

Tag

TFRC Contains A 6x histidine tag

TFRC Formulation

Liquid

TFRC Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TFRC family

SUBUNIT: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.

TFRC Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; SUBCELLULAR LOCATION: Transferrin receptor protein 1, serum form: Secreted.

TFRC FUNCTION According to UniProtKB Swiss Prot

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

TFRC Sequence

DDBJ

EMBL

GenBank

TFRC 3D structure

ModBase

TFRC interaction

STRING

TFRC Proteomic

PRIDE

TFRC Genome annotation

Ensembl

GeneID

KEGG

UCSC

TFRC Organism specific

CTD

MGI

TFRC Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TFRC Gene expression

Bgee

ArrayExpress

Genevestigator

TFRC Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY