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Mouse cd61 (aa 134 – 376)

Itgb3 Swiss Prot#

O54890

Itgb3 Protein names

Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)

Itgb3 Gene names

Itgb3

Organism

Mouse

Itgb3 Entry name

ITB3_MOUSE

Itgb3 Codon optimized cDNA(gene) Clone

Itgb3 Cat #

RPV0767

Tag

Itgb3 contains A 6x histidine tag

Itgb3 Formulation

Liquid

Itgb3 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Itgb3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Itgb3 Protein

Itgb3 Cat #

PV0767

Itgb3 Source

recombinant.

Itgb3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Itgb3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Itgb3 Activity

N/A

Tag

Itgb3 Contains A 6x histidine tag

Itgb3 Formulation

Liquid

Itgb3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Itgb3 family

SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIB or alpha-V. Interacts with FLNB and COMP. Interacts with PDIA6 following platelet stimulation (By similarity).

Itgb3 Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

Itgb3 FUNCTION According to UniProtKB Swiss Prot

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Itgb3 Sequence

DDBJ

EMBL

GenBank

Itgb3 3D structure

ModBase

Itgb3 interaction

STRING

Itgb3 Proteomic

PRIDE

Itgb3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Itgb3 Organism specific

CTD

MGI

Itgb3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Itgb3 Gene expression

Bgee

ArrayExpress

Genevestigator

Itgb3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY