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| Human cd46 (aa 35 – 343) |
| MCP Swiss Prot# | | P15529 |
| MCP Protein names | | Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46) |
| MCP Gene names | | CD46 MCP MIC10 |
| Organism | | Human |
| MCP Entry name | | MCP_HUMAN |
| MCP Codon optimized cDNA(gene) Clone |
| MCP Cat # | | RPV0711 |
| Tag | | MCP contains A 6x histidine tag |
| MCP Formulation | | Liquid |
| MCP Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| MCP Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant MCP Protein |
| MCP Cat # | | PV0711 |
| MCP Source | | recombinant. |
| MCP Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| MCP Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| MCP Activity | | N/A |
| Tag | | MCP Contains A 6x histidine tag |
| MCP Formulation | | Liquid |
| MCP Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant MCP Products | | For pricing and availability Click Here >>> |
| MCP family | | SUBUNIT: Interacts with C3b and C4b. Binds to Measles virus H protein, to Human herpesvirus 6 GH protein and to human adenovirus B/D PIV/fiber protein, and acts as a receptor for these viruses. Binds to Streptococcus pyogenes M protein and to type IV pili from Neisseria, and may act as a receptor for these pathogenic bacteria. |
| MCP Subcellular locations | | SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide. |
| MCP FUNCTION According to UniProtKB Swiss Prot | | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. |
| MCP Sequence | | DDBJ | EMBL | GenBank |
| MCP 3D structure | | ModBase |
| MCP interaction | | STRING |
| MCP Proteomic | | PRIDE |
| MCP Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| MCP Organism specific | | CTD | MGI |
| MCP Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| MCP Gene expression | | Bgee | ArrayExpress | Genevestigator |
| MCP Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
