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Human cd41 (aa 32 – 420)

GP2B Swiss Prot#

P08514

GP2B Protein names

Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]

GP2B Gene names

ITGA2B GP2B ITGAB

Organism

Human

GP2B Entry name

ITA2B_HUMAN

GP2B Codon optimized cDNA(gene) Clone

GP2B Cat #

RPV0693

Tag

GP2B contains A 6x histidine tag

GP2B Formulation

Liquid

GP2B Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

GP2B Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant GP2B Protein

GP2B Cat #

PV0693

GP2B Source

recombinant.

GP2B Applications

Western Blot, SDS-Page or may be used for other applications determined by user

GP2B Purity

>90%, as determined by SDS-PAGE under reducing conditions

GP2B Activity

N/A

Tag

GP2B Contains A 6x histidine tag

GP2B Formulation

Liquid

GP2B Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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GP2B family

SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181.

GP2B Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

GP2B FUNCTION According to UniProtKB Swiss Prot

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

GP2B Sequence

DDBJ

EMBL

GenBank

GP2B 3D structure

ModBase

GP2B interaction

STRING

GP2B Proteomic

PRIDE

GP2B Genome annotation

Ensembl

GeneID

KEGG

UCSC

GP2B Organism specific

CTD

MGI

GP2B Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

GP2B Gene expression

Bgee

ArrayExpress

Genevestigator

GP2B Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY