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Human cd4 (aa 26 – 396)

CD4 Swiss Prot#

P01730

CD4 Protein names

T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)

CD4 Gene names

CD4

Organism

Human

CD4 Entry name

CD4_HUMAN

CD4 Codon optimized cDNA(gene) Clone

CD4 Cat #

RPV0687

Tag

CD4 contains A 6x histidine tag

CD4 Formulation

Liquid

CD4 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CD4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CD4 Protein

CD4 Cat #

PV0687

CD4 Source

recombinant.

CD4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CD4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CD4 Activity

N/A

Tag

CD4 Contains A 6x histidine tag

CD4 Formulation

Liquid

CD4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CD4 family

SUBUNIT: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.

CD4 Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

CD4 FUNCTION According to UniProtKB Swiss Prot

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

CD4 Sequence

DDBJ

EMBL

GenBank

CD4 3D structure

ModBase

CD4 interaction

STRING

CD4 Proteomic

PRIDE

CD4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CD4 Organism specific

CTD

MGI

CD4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CD4 Gene expression

Bgee

ArrayExpress

Genevestigator

CD4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY