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Mouse cd358 (aa 42 – 349)

Dr6 Swiss Prot#

Q9EPU5

Dr6 Protein names

Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)

Dr6 Gene names

Tnfrsf21 Dr6

Organism

Mouse

Dr6 Entry name

TNR21_MOUSE

Dr6 Codon optimized cDNA(gene) Clone

Dr6 Cat #

RPV0651

Tag

Dr6 contains A 6x histidine tag

Dr6 Formulation

Liquid

Dr6 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Dr6 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Dr6 Protein

Dr6 Cat #

PV0651

Dr6 Source

recombinant.

Dr6 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Dr6 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Dr6 Activity

N/A

Tag

Dr6 Contains A 6x histidine tag

Dr6 Formulation

Liquid

Dr6 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Dr6 family

SUBUNIT: Associates with TRADD (By similarity). Interacts with N-APP.

Dr6 Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Probable).

Dr6 FUNCTION According to UniProtKB Swiss Prot

May activate NF-kappa-B and promote apoptosis (By similarity). May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Dr6 Sequence

DDBJ

EMBL

GenBank

Dr6 3D structure

ModBase

Dr6 interaction

STRING

Dr6 Proteomic

PRIDE

Dr6 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Dr6 Organism specific

CTD

MGI

Dr6 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Dr6 Gene expression

Bgee

ArrayExpress

Genevestigator

Dr6 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY