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Rat cd324 (aa 24 – 420)

Cdh1 Swiss Prot#

Q9R0T4

Cdh1 Protein names

Cadherin-1 (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]

Cdh1 Gene names

Cdh1

Organism

Rat

Cdh1 Entry name

CADH1_RAT

Cdh1 Codon optimized cDNA(gene) Clone

Cdh1 Cat #

RPV0593

Tag

Cdh1 contains A 6x histidine tag

Cdh1 Formulation

Liquid

Cdh1 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cdh1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cdh1 Protein

Cdh1 Cat #

PV0593

Cdh1 Source

recombinant.

Cdh1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cdh1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cdh1 Activity

N/A

Tag

Cdh1 Contains A 6x histidine tag

Cdh1 Formulation

Liquid

Cdh1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cdh1 family

SUBUNIT: Homodimer; disulfide-linked. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLGAP5 (By similarity). Interacts with TBC1D2. Interacts with LIMA1. Interacts with CAV1. Interacts with the TRPV4 and CTNNB1 complex (By similarity).

Cdh1 Subcellular locations

SUBCELLULAR LOCATION: Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome (By similarity). Golgi apparatus, trans-Golgi network (By similarity). Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane (By similarity).

Cdh1 FUNCTION According to UniProtKB Swiss Prot

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity).; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).

Cdh1 Sequence

DDBJ

EMBL

GenBank

Cdh1 3D structure

ModBase

Cdh1 interaction

STRING

Cdh1 Proteomic

PRIDE

Cdh1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cdh1 Organism specific

CTD

MGI

Cdh1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cdh1 Gene expression

Bgee

ArrayExpress

Genevestigator

Cdh1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY