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Mouse cd321 (aa 27 – 238)

Jam1 Swiss Prot#

O88792

Jam1 Protein names

Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD antigen CD321)

Jam1 Gene names

F11r Jam1 Jcam Jcam1

Organism

Mouse

Jam1 Entry name

JAM1_MOUSE

Jam1 Codon optimized cDNA(gene) Clone

Jam1 Cat #

RPV0586

Tag

Jam1 contains A 6x histidine tag

Jam1 Formulation

Liquid

Jam1 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Jam1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Jam1 Protein

Jam1 Cat #

PV0586

Jam1 Source

recombinant.

Jam1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Jam1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Jam1 Activity

N/A

Tag

Jam1 Contains A 6x histidine tag

Jam1 Formulation

Liquid

Jam1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Jam1 family

SUBUNIT: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity).

Jam1 Subcellular locations

SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.

Jam1 FUNCTION According to UniProtKB Swiss Prot

Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity).

Jam1 Sequence

DDBJ

EMBL

GenBank

Jam1 3D structure

ModBase

Jam1 interaction

STRING

Jam1 Proteomic

PRIDE

Jam1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Jam1 Organism specific

CTD

MGI

Jam1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Jam1 Gene expression

Bgee

ArrayExpress

Genevestigator

Jam1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY