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Human cd317 (aa 49 – 161)

BST2 Swiss Prot#

Q10589

BST2 Protein names

Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317)

BST2 Gene names

BST2

Organism

Human

BST2 Entry name

BST2_HUMAN

BST2 Codon optimized cDNA(gene) Clone

BST2 Cat #

RPV0570

Tag

BST2 contains A 6x histidine tag

BST2 Formulation

Liquid

BST2 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

BST2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant BST2 Protein

BST2 Cat #

PV0570

BST2 Source

recombinant.

BST2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

BST2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

BST2 Activity

N/A

Tag

BST2 Contains A 6x histidine tag

BST2 Formulation

Liquid

BST2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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BST2 family

SUBUNIT: Parralel homodimer; disulfide-linked. May form homotetramers under reducing conditions.

BST2 Subcellular locations

SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Note=Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Targeted to the trans-Golgi network by viral VPU protein.

BST2 FUNCTION According to UniProtKB Swiss Prot

May be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of enveloped virus from the cell surface. Active against at least four virus families: retroviruses, filoviruses, arenaviruses, and herpesviruses. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. May play a role in B-cell activation in rheumatoid arthritis.

BST2 Sequence

DDBJ

EMBL

GenBank

BST2 3D structure

ModBase

BST2 interaction

STRING

BST2 Proteomic

PRIDE

BST2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

BST2 Organism specific

CTD

MGI

BST2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BST2 Gene expression

Bgee

ArrayExpress

Genevestigator

BST2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY