All rights
reserved
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
||||||||||||||||||||||||||||||||||
|
|||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rat cd31 (aa 18 – 589) |
| Pecam Swiss Prot# | | Q3SWT0 |
| Pecam Protein names | | Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31) |
| Pecam Gene names | | Pecam1 Pecam |
| Organism | | Rat |
| Pecam Entry name | | PECA1_RAT |
| Pecam Codon optimized cDNA(gene) Clone |
| Pecam Cat # | | RPV0559 |
| Tag | | Pecam contains A 6x histidine tag |
| Pecam Formulation | | Liquid |
| Pecam Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Pecam Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Pecam Protein |
| Pecam Cat # | | PV0559 |
| Pecam Source | | recombinant. |
| Pecam Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Pecam Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Pecam Activity | | N/A |
| Tag | | Pecam Contains A 6x histidine tag |
| Pecam Formulation | | Liquid |
| Pecam Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Pecam Products | | For pricing and availability Click Here >>> |
| Pecam family | | SUBUNIT: Interacts with PTPN11. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ (By similarity). |
| Pecam Subcellular locations | | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell junction (By similarity). Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells (By similarity). |
| Pecam FUNCTION According to UniProtKB Swiss Prot | | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation. Induces susceptibility to atherosclerosis (By similarity). |
| Pecam Sequence | | DDBJ | EMBL | GenBank |
| Pecam 3D structure | | ModBase |
| Pecam interaction | | STRING |
| Pecam Proteomic | | PRIDE |
| Pecam Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Pecam Organism specific | | CTD | MGI |
| Pecam Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Pecam Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Pecam Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
