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Human cd31 (aa 28 – 601)

PECAM1 Swiss Prot#

P16284

PECAM1 Protein names

Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)

PECAM1 Gene names

PECAM1

Organism

Human

PECAM1 Entry name

PECA1_HUMAN

PECAM1 Codon optimized cDNA(gene) Clone

PECAM1 Cat #

RPV0557

Tag

PECAM1 contains A 6x histidine tag

PECAM1 Formulation

Liquid

PECAM1 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PECAM1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PECAM1 Protein

PECAM1 Cat #

PV0557

PECAM1 Source

recombinant.

PECAM1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PECAM1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PECAM1 Activity

N/A

Tag

PECAM1 Contains A 6x histidine tag

PECAM1 Formulation

Liquid

PECAM1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PECAM1 family

SUBUNIT: Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ.

PECAM1 Subcellular locations

SUBCELLULAR LOCATION: Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.; SUBCELLULAR LOCATION: Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

PECAM1 FUNCTION According to UniProtKB Swiss Prot

Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic

shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

PECAM1 Sequence

DDBJ

EMBL

GenBank

PECAM1 3D structure

ModBase

PECAM1 interaction

STRING

PECAM1 Proteomic

PRIDE

PECAM1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PECAM1 Organism specific

CTD

MGI

PECAM1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PECAM1 Gene expression

Bgee

ArrayExpress

Genevestigator

PECAM1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY