All rights
reserved
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
||||||||||||||||||||||||||||||||||
|
|||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rat CD305 (aa 22 – 144) |
| Lair1 Swiss Prot# | | P0C1X9 |
| Lair1 Protein names | | Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (rLAIR1) (CD antigen CD305) |
| Lair1 Gene names | | Lair1 |
| Organism | | Rat |
| Lair1 Entry name | | LAIR1_RAT |
| Lair1 Codon optimized cDNA(gene) Clone |
| Lair1 Cat # | | RPV0551 |
| Tag | | Lair1 contains A 6x histidine tag |
| Lair1 Formulation | | Liquid |
| Lair1 Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Lair1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Lair1 Protein |
| Lair1 Cat # | | PV0551 |
| Lair1 Source | | recombinant. |
| Lair1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Lair1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Lair1 Activity | | N/A |
| Tag | | Lair1 Contains A 6x histidine tag |
| Lair1 Formulation | | Liquid |
| Lair1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Lair1 Products | | For pricing and availability Click Here >>> |
| Lair1 family | | SUBUNIT: Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK (By similarity). |
| Lair1 Subcellular locations | | SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). |
| Lair1 FUNCTION According to UniProtKB Swiss Prot | | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity). |
| Lair1 Sequence | | DDBJ | EMBL | GenBank |
| Lair1 3D structure | | ModBase |
| Lair1 interaction | | STRING |
| Lair1 Proteomic | | PRIDE |
| Lair1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Lair1 Organism specific | | CTD | MGI |
| Lair1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Lair1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Lair1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
