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Rat cd295 (aa 535 – 629 )

Fa Swiss Prot#

Q62959

Fa Protein names

Leptin receptor (LEP-R) (OB receptor) (OB-R) (CD antigen CD295)

Fa Gene names

Lepr Fa Obr

Organism

Rat

Fa Entry name

LEPR_RAT

Fa Codon optimized cDNA(gene) Clone

Fa Cat #

RPV0505

Tag

Fa contains A 6x histidine tag

Fa Formulation

Liquid

Fa Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Fa Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Fa Protein

Fa Cat #

PV0505

Fa Source

recombinant.

Fa Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Fa Purity

>90%, as determined by SDS-PAGE under reducing conditions

Fa Activity

N/A

Tag

Fa Contains A 6x histidine tag

Fa Formulation

Liquid

Fa Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Place Order for Recombinant Fa Products

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Fa family

SUBUNIT: On leptin stimulation, homodimerizes (By similarity). The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits LRb signaling (By similarity).

Fa Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform E: Secreted (Probable).

Fa FUNCTION According to UniProtKB Swiss Prot

Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3 (By similarity). Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).; Isoform A may act to transport leptin to the cerebrospinal fluid.; The putative soluble isoform E could function as a transport protein.

Fa Sequence

DDBJ

EMBL

GenBank

Fa 3D structure

ModBase

Fa interaction

STRING

Fa Proteomic

PRIDE

Fa Genome annotation

Ensembl

GeneID

KEGG

UCSC

Fa Organism specific

CTD

MGI

Fa Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Fa Gene expression

Bgee

ArrayExpress

Genevestigator

Fa Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY