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Mouse cd295 (aa 637 – 729)

Db Swiss Prot#

P48356

Db Protein names

Leptin receptor (LEP-R) (B219) (OB receptor) (OB-R) (CD antigen CD295)

Db Gene names

Lepr Db Obr

Organism

Mouse

Db Entry name

LEPR_MOUSE

Db Codon optimized cDNA(gene) Clone

Db Cat #

RPV0504

Tag

Db contains A 6x histidine tag

Db Formulation

Liquid

Db Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Db Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Db Protein

Db Cat #

PV0504

Db Source

recombinant.

Db Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Db Purity

>90%, as determined by SDS-PAGE under reducing conditions

Db Activity

N/A

Tag

Db Contains A 6x histidine tag

Db Formulation

Liquid

Db Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Db family

SUBUNIT: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits JAK/STAT signaling.

Db Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform E: Secreted (Probable).

Db FUNCTION According to UniProtKB Swiss Prot

Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.; Isoform A may act to transport leptin to the cerebrospinal fluid (By similarity).; Isoform E could function as a transport protein.

Db Sequence

DDBJ

EMBL

GenBank

Db 3D structure

ModBase

Db interaction

STRING

Db Proteomic

PRIDE

Db Genome annotation

Ensembl

GeneID

KEGG

UCSC

Db Organism specific

CTD

MGI

Db Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Db Gene expression

Bgee

ArrayExpress

Genevestigator

Db Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY