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Rat cd29 (aa 21 – 421)

Itgb1 Swiss Prot#

P49134

Itgb1 Protein names

Integrin beta-1 (Beta oligodendroglia) (Beta OL) (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29)

Itgb1 Gene names

Itgb1

Organism

Rat

Itgb1 Entry name

ITB1_RAT

Itgb1 Codon optimized cDNA(gene) Clone

Itgb1 Cat #

RPV0495

Tag

Itgb1 contains A 6x histidine tag

Itgb1 Formulation

Liquid

Itgb1 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Itgb1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Itgb1 Protein

Itgb1 Cat #

PV0495

Itgb1 Source

recombinant.

Itgb1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Itgb1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Itgb1 Activity

N/A

Tag

Itgb1 Contains A 6x histidine tag

Itgb1 Formulation

Liquid

Itgb1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Itgb1 family

SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of GNB2L1 and SRC (By similarity). Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region) (By similarity).

Itgb1 Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Melanosome (By similarity).

Itgb1 FUNCTION According to UniProtKB Swiss Prot

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation (By similarity). Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity).

Itgb1 Sequence

DDBJ

EMBL

GenBank

Itgb1 3D structure

ModBase

Itgb1 interaction

STRING

Itgb1 Proteomic

PRIDE

Itgb1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Itgb1 Organism specific

CTD

MGI

Itgb1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Itgb1 Gene expression

Bgee

ArrayExpress

Genevestigator

Itgb1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY