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Mouse cd29 (aa 21 – 421)
Itgb1 Swiss Prot#
P09055
Itgb1 Protein names
Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29)
Itgb1 Gene names
Itgb1
Organism
Mouse
Itgb1 Entry name
ITB1_MOUSE
Itgb1 Codon optimized cDNA(gene) Clone
Itgb1 Cat #
RPV0494
Tag
Itgb1 contains A 6x histidine tag
Itgb1 Formulation
Liquid
Itgb1 Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Itgb1 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Itgb1 Protein
Itgb1 Cat #
PV0494
Itgb1 Source
recombinant.
Itgb1 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
Itgb1 Purity
>90%, as determined by SDS-PAGE under reducing conditions
Itgb1 Activity
N/A
Tag
Itgb1 Contains A 6x histidine tag
Itgb1 Formulation
Liquid
Itgb1 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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Itgb1 family
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of GNB2L1 and SRC (By similarity). Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region) (By similarity).
Itgb1 Subcellular locations
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). Melanosome (By similarity).
Itgb1 FUNCTION According to UniProtKB Swiss Prot
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
Itgb1 Sequence
DDBJ EMBL GenBank
Itgb1 3D structure
ModBase
Itgb1 interaction
STRING
Itgb1 Proteomic
PRIDE
Itgb1 Genome annotation
Ensembl GeneID KEGG UCSC
Itgb1 Organism specific
CTD MGI
Itgb1 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Itgb1 Gene expression
Bgee ArrayExpress Genevestigator
Itgb1 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY