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Rat CD284 (aa 26 – 426)

Tlr4 Swiss Prot#

Q9QX05

Tlr4 Protein names

Toll-like receptor 4 (Toll4) (CD antigen CD284)

Tlr4 Gene names

Tlr4

Organism

Rat

Tlr4 Entry name

TLR4_RAT

Tlr4 Codon optimized cDNA(gene) Clone

Tlr4 Cat #

RPV0485

Tag

Tlr4 contains A 6x histidine tag

Tlr4 Formulation

Liquid

Tlr4 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Tlr4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Tlr4 Protein

Tlr4 Cat #

PV0485

Tlr4 Source

recombinant.

Tlr4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Tlr4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Tlr4 Activity

N/A

Tag

Tlr4 Contains A 6x histidine tag

Tlr4 Formulation

Liquid

Tlr4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Tlr4 family

SUBUNIT: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4 (By similarity). Interacts with CNPY3 (By similarity).

Tlr4 Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).

Tlr4 FUNCTION According to UniProtKB Swiss Prot

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Tlr4 Sequence

DDBJ

EMBL

GenBank

Tlr4 3D structure

ModBase

Tlr4 interaction

STRING

Tlr4 Proteomic

PRIDE

Tlr4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Tlr4 Organism specific

CTD

MGI

Tlr4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Tlr4 Gene expression

Bgee

ArrayExpress

Genevestigator

Tlr4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY