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Human cd283 (aa 24 –424)

TLR3 Swiss Prot#

O15455

TLR3 Protein names

Toll-like receptor 3 (CD antigen CD283)

TLR3 Gene names

TLR3

Organism

Human

TLR3 Entry name

TLR3_HUMAN

TLR3 Codon optimized cDNA(gene) Clone

TLR3 Cat #

RPV0480

Tag

TLR3 contains A 6x histidine tag

TLR3 Formulation

Liquid

TLR3 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TLR3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TLR3 Protein

TLR3 Cat #

PV0480

TLR3 Source

recombinant.

TLR3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TLR3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

TLR3 Activity

N/A

Tag

TLR3 Contains A 6x histidine tag

TLR3 Formulation

Liquid

TLR3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TLR3 family

SUBUNIT: Interacts with MYD88 via their respective TIR domains. Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with TICAM1. Homodimer formation is triggered by ligand binding and is required for TLR3 signaling. Binding of double-stranded RNA is required for the interaction with SRC.

TLR3 Subcellular locations

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.

TLR3 FUNCTION According to UniProtKB Swiss Prot

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

TLR3 Sequence

DDBJ

EMBL

GenBank

TLR3 3D structure

ModBase

TLR3 interaction

STRING

TLR3 Proteomic

PRIDE

TLR3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

TLR3 Organism specific

CTD

MGI

TLR3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TLR3 Gene expression

Bgee

ArrayExpress

Genevestigator

TLR3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY