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Human cd281 (aa 25 – 580)

KIAA0012 Swiss Prot#

Q15399

KIAA0012 Protein names

Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)

KIAA0012 Gene names

TLR1 KIAA0012

Organism

Human

KIAA0012 Entry name

TLR1_HUMAN

KIAA0012 Codon optimized cDNA(gene) Clone

KIAA0012 Cat #

RPV0474

Tag

KIAA0012 contains A 6x histidine tag

KIAA0012 Formulation

Liquid

KIAA0012 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

KIAA0012 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant KIAA0012 Protein

KIAA0012 Cat #

PV0474

KIAA0012 Source

recombinant.

KIAA0012 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

KIAA0012 Purity

>90%, as determined by SDS-PAGE under reducing conditions

KIAA0012 Activity

N/A

Tag

KIAA0012 Contains A 6x histidine tag

KIAA0012 Formulation

Liquid

KIAA0012 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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KIAA0012 family

SUBUNIT: Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.

KIAA0012 Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein (By similarity).

KIAA0012 FUNCTION According to UniProtKB Swiss Prot

Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

KIAA0012 Sequence

DDBJ

EMBL

GenBank

KIAA0012 3D structure

ModBase

KIAA0012 interaction

STRING

KIAA0012 Proteomic

PRIDE

KIAA0012 Genome annotation

Ensembl

GeneID

KEGG

UCSC

KIAA0012 Organism specific

CTD

MGI

KIAA0012 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

KIAA0012 Gene expression

Bgee

ArrayExpress

Genevestigator

KIAA0012 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY