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Human cd276 (aa 29 – 466)

B7H3 Swiss Prot#

Q5ZPR3

B7H3 Protein names

CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)

B7H3 Gene names

CD276 B7H3 PSEC0249 UNQ309/PRO352

Organism

Human

B7H3 Entry name

CD276_HUMAN

B7H3 Codon optimized cDNA(gene) Clone

B7H3 Cat #

RPV0461

Tag

B7H3 contains A 6x histidine tag

B7H3 Formulation

Liquid

B7H3 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

B7H3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant B7H3 Protein

B7H3 Cat #

PV0461

B7H3 Source

recombinant.

B7H3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

B7H3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

B7H3 Activity

N/A

Tag

B7H3 Contains A 6x histidine tag

B7H3 Formulation

Liquid

B7H3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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B7H3 family

SUBUNIT: Interacts with TREML2 and this interaction enhances T-cell activation.

B7H3 Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Probable).

B7H3 FUNCTION According to UniProtKB Swiss Prot

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

B7H3 Sequence

DDBJ

EMBL

GenBank

B7H3 3D structure

ModBase

B7H3 interaction

STRING

B7H3 Proteomic

PRIDE

B7H3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

B7H3 Organism specific

CTD

MGI

B7H3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

B7H3 Gene expression

Bgee

ArrayExpress

Genevestigator

B7H3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY