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| Rat cd26 (aa 29 – 429) |
| Cd26 Swiss Prot# | | P14740 |
| Cd26 Protein names | | Dipeptidyl peptidase 4 (EC 3.4.14.5) (Bile canaliculus domain-specific membrane glycoprotein) (Dipeptidyl peptidase IV) (DPP IV) (GP110 glycoprotein) (T-cell activation antigen CD26) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form); Dipeptidyl peptidase 4 60 kDa soluble form (Dipeptidyl peptidase IV 60 kDa soluble form)] |
| Cd26 Gene names | | Dpp4 Cd26 |
| Organism | | Rat |
| Cd26 Entry name | | DPP4_RAT |
| Cd26 Codon optimized cDNA(gene) Clone |
| Cd26 Cat # | | RPV0429 |
| Tag | | Cd26 contains A 6x histidine tag |
| Cd26 Formulation | | Liquid |
| Cd26 Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Cd26 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Cd26 Protein |
| Cd26 Cat # | | PV0429 |
| Cd26 Source | | recombinant. |
| Cd26 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Cd26 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Cd26 Activity | | N/A |
| Tag | | Cd26 Contains A 6x histidine tag |
| Cd26 Formulation | | Liquid |
| Cd26 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Cd26 Products | | For pricing and availability Click Here >>> |
| Cd26 family | | SUBUNIT: Monomer. Heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3 (By similarity). Homodimer. |
| Cd26 Subcellular locations | | SUBCELLULAR LOCATION: Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid (By similarity).; SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein (By similarity). Cell projection, invadopodium membrane; Single-pass type II membrane protein (By similarity). Cell projection, lamellipodium membrane; Single-pass type II membrane protein (By similarity). Cell junction (By similarity). Membrane raft (By similarity). Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell | adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (By similarity). |
| Cd26 FUNCTION According to UniProtKB Swiss Prot | | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones (By similarity). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. |
| Cd26 Sequence | | DDBJ | EMBL | GenBank |
| Cd26 3D structure | | ModBase |
| Cd26 interaction | | STRING |
| Cd26 Proteomic | | PRIDE |
| Cd26 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Cd26 Organism specific | | CTD | MGI |
| Cd26 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Cd26 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Cd26 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
