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Human Cd247 (aa 22 – 164)

CD3Z Swiss Prot#

P20963

CD3Z Protein names

T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)

CD3Z Gene names

CD247 CD3Z T3Z TCRZ

Organism

Human

CD3Z Entry name

CD3Z_HUMAN

CD3Z Codon optimized cDNA(gene) Clone

CD3Z Cat #

RPV0415

Tag

CD3Z contains A 6x histidine tag

CD3Z Formulation

Liquid

CD3Z Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CD3Z Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CD3Z Protein

CD3Z Cat #

PV0415

CD3Z Source

recombinant.

CD3Z Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CD3Z Purity

>90%, as determined by SDS-PAGE under reducing conditions

CD3Z Activity

N/A

Tag

CD3Z Contains A 6x histidine tag

CD3Z Formulation

Liquid

CD3Z Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CD3Z family

SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1; this interaction up-regulates the expression of the Fas ligand (FASLG) at the cell surface. Interacts with HIV-2 Nef protein; this interaction induces down-regulation of cell surface TCR/CD3 complexes. Interacts with SHB.

CD3Z Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

CD3Z FUNCTION According to UniProtKB Swiss Prot

Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

CD3Z Sequence

DDBJ

EMBL

GenBank

CD3Z 3D structure

ModBase

CD3Z interaction

STRING

CD3Z Proteomic

PRIDE

CD3Z Genome annotation

Ensembl

GeneID

KEGG

UCSC

CD3Z Organism specific

CTD

MGI

CD3Z Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CD3Z Gene expression

Bgee

ArrayExpress

Genevestigator

CD3Z Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY