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| Human cd227 (aa 921 –1158) |
| Muc-1 Swiss Prot# | | P15941 |
| Muc-1 Protein names | | Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Carcinoma-associated mucin) (Episialin) (H23AG) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] |
| Muc-1 Gene names | | Muc1 Muc-1 |
| Organism | | Human |
| Muc-1 Entry name | | MUC1_HUMAN |
| Muc-1 Codon optimized cDNA(gene) Clone |
| Muc-1 Cat # | | RPV0372 |
| Tag | | Muc-1 contains A 6x histidine tag |
| Muc-1 Formulation | | Liquid |
| Muc-1 Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Muc-1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Muc-1 Protein |
| Muc-1 Cat # | | PV0372 |
| Muc-1 Source | | recombinant. |
| Muc-1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Muc-1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Muc-1 Activity | | N/A |
| Tag | | Muc-1 Contains A 6x histidine tag |
| Muc-1 Formulation | | Liquid |
| Muc-1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Muc-1 Products | | For pricing and availability Click Here >>> |
| Muc-1 family | | SUBUNIT: The alpha subunit forms a tight, non-covalent heterodimeric complex with the proteolytically-released beta-subunit. Interaction, via the tandem repeat region, with domain 1 of ICAM1 is implicated in cell migration and metastases. Isoform 1 binds directly the SH2 domain of GRB2, and forms a MUC1/GRB2/SOS1 complex involved in RAS signaling. The cytoplasmic tail (MUC1CT) interacts with several proteins such as SRC, CTNNB1 and ERBs. Interaction with the SH2 domain of CSK decreases interaction with GSK3B. Interacts with CTNNB1/beta-catenin and JUP/gamma-catenin and promotes cell adhesion. Interaction with JUP/gamma-catenin is induced by heregulin. Binds PRKCD, ERBB2, ERBB3 and ERBB4. Heregulin (HRG) stimulates the interaction with ERBB2 and, to a much lesser extent, the interaction with ERBB3 and ERBB4. Interacts with P53 in response to DNA damage. Interacts with KLF4. Interacts with estrogen receptor alpha/ESR1, through its DNA-binding domain, and stimulates its transcription activity. Binds ADAM17. |
| Muc-1 Subcellular locations | | SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.; SUBCELLULAR LOCATION: Isoform 5: Secreted. ; SUBCELLULAR LOCATION: Isoform 7: Secreted. ; SUBCELLULAR LOCATION: Isoform 9: Secreted. ; SUBCELLULAR LOCATION: Mucin-1 subunit beta: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus. |
| Muc-1 FUNCTION According to UniProtKB Swiss Prot | | The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. |
| Muc-1 Sequence | | DDBJ | EMBL | GenBank |
| Muc-1 3D structure | | ModBase |
| Muc-1 interaction | | STRING |
| Muc-1 Proteomic | | PRIDE |
| Muc-1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Muc-1 Organism specific | | CTD | MGI |
| Muc-1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Muc-1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Muc-1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
