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Human cd209 (aa 59 – 404)

CLEC4L Swiss Prot#

Q9NNX6

CLEC4L Protein names

CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209)

CLEC4L Gene names

CD209 CLEC4L

Organism

Human

CLEC4L Entry name

CD209_HUMAN

CLEC4L Codon optimized cDNA(gene) Clone

CLEC4L Cat #

RPV0339

Tag

CLEC4L contains A 6x histidine tag

CLEC4L Formulation

Liquid

CLEC4L Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CLEC4L Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CLEC4L Protein

CLEC4L Cat #

PV0339

CLEC4L Source

recombinant.

CLEC4L Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CLEC4L Purity

>90%, as determined by SDS-PAGE under reducing conditions

CLEC4L Activity

N/A

Tag

CLEC4L Contains A 6x histidine tag

CLEC4L Formulation

Liquid

CLEC4L Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CLEC4L family

SUBUNIT: Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E.

CLEC4L Subcellular locations

SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type II membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type II membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type II membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type II membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 5: Cell membrane; Single-pass type II membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 6: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 7: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 8: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 9: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 10: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 11: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 12: Secreted (Probable).

CLEC4L FUNCTION According to UniProtKB Swiss Prot

Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.; On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

CLEC4L Sequence

DDBJ

EMBL

GenBank

CLEC4L 3D structure

ModBase

CLEC4L interaction

STRING

CLEC4L Proteomic

PRIDE

CLEC4L Genome annotation

Ensembl

GeneID

KEGG

UCSC

CLEC4L Organism specific

CTD

MGI

CLEC4L Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CLEC4L Gene expression

Bgee

ArrayExpress

Genevestigator

CLEC4L Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY