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Mouse cd184 (extracellular domain fused GFP at C-terminal)

Cmkar4 Swiss Prot#

P70658

Cmkar4 Protein names

C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Pre-B-cell-derived chemokine receptor) (PB-CKR) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)

Cmkar4 Gene names

Cxcr4 Cmkar4 Lestr Sdf1r

Organism

Mouse

Cmkar4 Entry name

CXCR4_MOUSE

Cmkar4 Codon optimized cDNA(gene) Clone

Cmkar4 Cat #

RPV0283

Tag

Cmkar4 contains A 6x histidine tag

Cmkar4 Formulation

Liquid

Cmkar4 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cmkar4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cmkar4 Protein

Cmkar4 Cat #

PV0283

Cmkar4 Source

recombinant.

Cmkar4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cmkar4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cmkar4 Activity

N/A

Tag

Cmkar4 Contains A 6x histidine tag

Cmkar4 Formulation

Liquid

Cmkar4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cmkar4 family

SUBUNIT: Monomer (By similarity). Can form dimers (By similarity). Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels (By similarity). Interacts with CD164.

Cmkar4 Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity).

Cmkar4 FUNCTION According to UniProtKB Swiss Prot

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

Cmkar4 Sequence

DDBJ

EMBL

GenBank

Cmkar4 3D structure

ModBase

Cmkar4 interaction

STRING

Cmkar4 Proteomic

PRIDE

Cmkar4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cmkar4 Organism specific

CTD

MGI

Cmkar4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cmkar4 Gene expression

Bgee

ArrayExpress

Genevestigator

Cmkar4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY