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Human cd18 (aa 23 – 423)

CD18 Swiss Prot#

P05107

CD18 Protein names

Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)

CD18 Gene names

ITGB2 CD18 MFI7

Organism

Human

CD18 Entry name

ITB2_HUMAN

CD18 Codon optimized cDNA(gene) Clone

CD18 Cat #

RPV0267

Tag

CD18 contains A 6x histidine tag

CD18 Formulation

Liquid

CD18 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CD18 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CD18 Protein

CD18 Cat #

PV0267

CD18 Source

recombinant.

CD18 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CD18 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CD18 Activity

N/A

Tag

CD18 Contains A 6x histidine tag

CD18 Formulation

Liquid

CD18 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CD18 family

SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9.

CD18 Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

CD18 FUNCTION According to UniProtKB Swiss Prot

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.

CD18 Sequence

DDBJ

EMBL

GenBank

CD18 3D structure

ModBase

CD18 interaction

STRING

CD18 Proteomic

PRIDE

CD18 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CD18 Organism specific

CTD

MGI

CD18 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CD18 Gene expression

Bgee

ArrayExpress

Genevestigator

CD18 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY