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Rat cd163 (aa 39-365)

Cd163_predicted Swiss Prot#

D3Z9U2

Cd163_predicted Protein names

CD163 antigen (Predicted) (Uncharacterized protein)

Cd163_predicted Gene names

Cd163 Cd163_predicted rCG_29882

Organism

Rat

Cd163_predicted Entry name

D3Z9U2_RAT

Cd163_predicted Codon optimized cDNA(gene) Clone

Cd163_predicted Cat #

RPV0222

Tag

Cd163_predicted contains A 6x histidine tag

Cd163_predicted Formulation

Liquid

Cd163_predicted Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cd163_predicted Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cd163_predicted Protein

Cd163_predicted Cat #

PV0222

Cd163_predicted Source

recombinant.

Cd163_predicted Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cd163_predicted Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cd163_predicted Activity

N/A

Tag

Cd163_predicted Contains A 6x histidine tag

Cd163_predicted Formulation

Liquid

Cd163_predicted Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cd163_predicted family

-

Cd163_predicted Subcellular locations

-

Cd163_predicted FUNCTION According to UniProtKB Swiss Prot

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.; After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Cd163_predicted Sequence

DDBJ

EMBL

GenBank

Cd163_predicted 3D structure

ModBase

Cd163_predicted interaction

STRING

Cd163_predicted Proteomic

PRIDE

Cd163_predicted Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cd163_predicted Organism specific

CTD

MGI

Cd163_predicted Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cd163_predicted Gene expression

Bgee

ArrayExpress

Genevestigator

Cd163_predicted Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY