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Human CD163 (aa 42 – 366)

M130 Swiss Prot#

Q86VB7

M130 Protein names

Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)]

M130 Gene names

CD163 M130

Organism

Human

M130 Entry name

C163A_HUMAN

M130 Codon optimized cDNA(gene) Clone

M130 Cat #

RPV0220

Tag

M130 contains A 6x histidine tag

M130 Formulation

Liquid

M130 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

M130 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant M130 Protein

M130 Cat #

PV0220

M130 Source

recombinant.

M130 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

M130 Purity

>90%, as determined by SDS-PAGE under reducing conditions

M130 Activity

N/A

Tag

M130 Contains A 6x histidine tag

M130 Formulation

Liquid

M130 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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M130 family

SUBUNIT: Interacts with CSNK2B.

M130 Subcellular locations

SUBCELLULAR LOCATION: Soluble CD163: Secreted. ; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.

M130 FUNCTION According to UniProtKB Swiss Prot

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.; After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

M130 Sequence

DDBJ

EMBL

GenBank

M130 3D structure

ModBase

M130 interaction

STRING

M130 Proteomic

PRIDE

M130 Genome annotation

Ensembl

GeneID

KEGG

UCSC

M130 Organism specific

CTD

MGI

M130 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

M130 Gene expression

Bgee

ArrayExpress

Genevestigator

M130 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY