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Rat Cd155 (aa 21-343)

PVR Swiss Prot#

Q5U334

PVR Protein names

Poliovirus receptor

PVR Gene names

PVR

Organism

Rat

PVR Entry name

Q5U334_RAT

PVR Codon optimized cDNA(gene) Clone

PVR Cat #

RPV0182

Tag

PVR contains A 6x histidine tag

PVR Formulation

Liquid

PVR Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PVR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PVR Protein

PVR Cat #

PV0182

PVR Source

recombinant.

PVR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PVR Purity

>90%, as determined by SDS-PAGE under reducing conditions

PVR Activity

N/A

Tag

PVR Contains A 6x histidine tag

PVR Formulation

Liquid

PVR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PVR family

-

PVR Subcellular locations

-

PVR FUNCTION According to UniProtKB Swiss Prot

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.

PVR Sequence

DDBJ

EMBL

GenBank

PVR 3D structure

ModBase

PVR interaction

STRING

PVR Proteomic

PRIDE

PVR Genome annotation

Ensembl

GeneID

KEGG

UCSC

PVR Organism specific

CTD

MGI

PVR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PVR Gene expression

Bgee

ArrayExpress

Genevestigator

PVR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY