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Human cd155 (aa 21 – 343)

PVS Swiss Prot#

P15151

PVS Protein names

Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)

PVS Gene names

PVR PVS

Organism

Human

PVS Entry name

PVR_HUMAN

PVS Codon optimized cDNA(gene) Clone

PVS Cat #

RPV0180

Tag

PVS contains A 6x histidine tag

PVS Formulation

Liquid

PVS Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PVS Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PVS Protein

PVS Cat #

PV0180

PVS Source

recombinant.

PVS Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PVS Purity

>90%, as determined by SDS-PAGE under reducing conditions

PVS Activity

N/A

Tag

PVS Contains A 6x histidine tag

PVS Formulation

Liquid

PVS Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PVS family

SUBUNIT: Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid composed of VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT.

PVS Subcellular locations

SUBCELLULAR LOCATION: Isoform Alpha: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform Delta: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform Beta: Secreted. ; SUBCELLULAR LOCATION: Isoform Gamma: Secreted.

PVS FUNCTION According to UniProtKB Swiss Prot

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.

PVS Sequence

DDBJ

EMBL

GenBank

PVS 3D structure

ModBase

PVS interaction

STRING

PVS Proteomic

PRIDE

PVS Genome annotation

Ensembl

GeneID

KEGG

UCSC

PVS Organism specific

CTD

MGI

PVS Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PVS Gene expression

Bgee

ArrayExpress

Genevestigator

PVS Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY