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Human cd146 (aa 24 – 559)

MUC18 Swiss Prot#

P43121

MUC18 Protein names

Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)

MUC18 Gene names

MCAM MUC18

Organism

Human

MUC18 Entry name

MUC18_HUMAN

MUC18 Codon optimized cDNA(gene) Clone

MUC18 Cat #

RPV0157

Tag

MUC18 contains A 6x histidine tag

MUC18 Formulation

Liquid

MUC18 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MUC18 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MUC18 Protein

MUC18 Cat #

PV0157

MUC18 Source

recombinant.

MUC18 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MUC18 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MUC18 Activity

N/A

Tag

MUC18 Contains A 6x histidine tag

MUC18 Formulation

Liquid

MUC18 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MUC18 family

-

MUC18 Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

MUC18 FUNCTION According to UniProtKB Swiss Prot

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

MUC18 Sequence

DDBJ

EMBL

GenBank

MUC18 3D structure

ModBase

MUC18 interaction

STRING

MUC18 Proteomic

PRIDE

MUC18 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MUC18 Organism specific

CTD

MGI

MUC18 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MUC18 Gene expression

Bgee

ArrayExpress

Genevestigator

MUC18 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY