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Mouse cd124 (aa 26 – 233)

Il4ra Swiss Prot#

P16382

Il4ra Protein names

Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]

Il4ra Gene names

Il4r Il4ra

Organism

Mouse

Il4ra Entry name

IL4RA_MOUSE

Il4ra Codon optimized cDNA(gene) Clone

Il4ra Cat #

RPV0096

Tag

Il4ra contains A 6x histidine tag

Il4ra Formulation

Liquid

Il4ra Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Il4ra Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Il4ra Protein

Il4ra Cat #

PV0096

Il4ra Source

recombinant.

Il4ra Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Il4ra Purity

>90%, as determined by SDS-PAGE under reducing conditions

Il4ra Activity

N/A

Tag

Il4ra Contains A 6x histidine tag

Il4ra Formulation

Liquid

Il4ra Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Il4ra family

SUBUNIT: The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region. In Th1 cells, binds the N-terminal 50 amino acids of SOCS5, which inhibits JAK1 interaction, STAT6 activation and Th2 cell differentiation. SOCS5 interaction is independent of tyrosine phosphorylation.

Il4ra Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform 2: Secreted.

Il4ra FUNCTION According to UniProtKB Swiss Prot

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

Il4ra Sequence

DDBJ

EMBL

GenBank

Il4ra 3D structure

ModBase

Il4ra interaction

STRING

Il4ra Proteomic

PRIDE

Il4ra Genome annotation

Ensembl

GeneID

KEGG

UCSC

Il4ra Organism specific

CTD

MGI

Il4ra Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Il4ra Gene expression

Bgee

ArrayExpress

Genevestigator

Il4ra Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY