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Mouse cd11b (aa 164 – 338)

Itgam Swiss Prot#

P05555

Itgam Protein names

Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (CD antigen CD11b)

Itgam Gene names

Itgam

Organism

Mouse

Itgam Entry name

ITAM_MOUSE

Itgam Codon optimized cDNA(gene) Clone

Itgam Cat #

RPV0079

Tag

Itgam contains A 6x histidine tag

Itgam Formulation

Liquid

Itgam Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Itgam Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Itgam Protein

Itgam Cat #

PV0079

Itgam Source

recombinant.

Itgam Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Itgam Purity

>90%, as determined by SDS-PAGE under reducing conditions

Itgam Activity

N/A

Tag

Itgam Contains A 6x histidine tag

Itgam Formulation

Liquid

Itgam Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Itgam family

SUBUNIT: Heterodimer of an alpha and a beta chain. Alpha-M associates with beta-2. Interacts with JAM3 (By similarity).

Itgam Subcellular locations

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

Itgam FUNCTION According to UniProtKB Swiss Prot

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Alpha-M/beta-2 play a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the alpha-M subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity.

Itgam Sequence

DDBJ

EMBL

GenBank

Itgam 3D structure

ModBase

Itgam interaction

STRING

Itgam Proteomic

PRIDE

Itgam Genome annotation

Ensembl

GeneID

KEGG

UCSC

Itgam Organism specific

CTD

MGI

Itgam Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Itgam Gene expression

Bgee

ArrayExpress

Genevestigator

Itgam Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY